上海针灸杂志Issue(8)：707-710,4.DOI:10.13460/j.issn.1005-0957.2015.08.0707
基于代谢组学的隔药灸脐法治疗原发性痛经的机理研究
Metabonomics-based Mechanism Study on Herb-partitioned Moxibustion at Umbilicus for Primary Dysmenorrhea
摘要
Abstract
ObjectiveTo explore the mechanism of herb-partitioned moxibustion at umbilicus in treating primarydysmenorrhea based on metabonomics.MethodTwenty patients with primary dysmenorrhea were randomized into two groups to respectively receive herb-partitioned moxibustion at umbilicus and moxa-stick moxibustion at umbilicus. After treatment for 3 menstrualcycles, Visual Analogue Scale (VAS) was used to evaluate abdominal pain, and LC-MS-based metabonomics analysis was adopted to detect the change of plasma metabolites.ResultAfter intervention, the VAS scores decreased with the menstrual cycles in both groups. The decrease of VAS score in herb-partitioned moxibustion group was more significant than that in moxa-stick moxibustion group (P<0.05); herb-partitioned moxibustion at umbilicus up-regulated the contents of 20α-dihydroprogesterone, pregnenolone, prostaglandin E2and-propalanine, and down-regulated the contents of estrone and prostaglandin H2in plasma; moxa-stick moxibustion decreased the content of 5’-pyridoxal phosphate.ConclusionThe two methods both can improve abdominal pain in primary dysmenorrhea, while herb-partitioned moxibustion can produce a more significant efficacy than moxa-stick moxibustion, and its effect is possibly realized via regulating estrone, progesterone, and prostaglandin.关键词
痛经/间接灸/代谢组学/隔药灸/穴,神阙/艾条灸Key words
Dysmenorrhea/Indirect moxibustion/Metabonomics/Herb-partitioned moxibustion/Point, Shenque (CV8)/Moxa stick moxibustion分类
医药卫生引用本文复制引用
杨星月,马玉侠,杜冬青,高树中..基于代谢组学的隔药灸脐法治疗原发性痛经的机理研究[J].上海针灸杂志,2015,(8):707-710,4.基金项目
国家重点基础研究发展计划项目(2007CB512703) （2007CB512703）
国家自然科学基金面上项目(30973789) （30973789）
