陕西医学杂志Issue(8)：994-995,2.DOI:10.3969/j.issn.1000-7377.2015.08.028
风湿性心脏瓣膜病患者血清 Ang（1-7）浓度与心房颤动的发生相关性分析∗
The Correlation analysis between the serum concentration of ang(1-7)in the patients with rheumatic valvular heart disease and the occurrence of atrial fibrillation
摘要
Abstract
Objective:By analysis of the correlation between the serum Ang (1-7 )in the patients with rheumatic valvular heart disease and the occurrence of atrial fibrillation,to reveal the function of the Ang(1-7)in the occurrence and maintaining of atrial fibrillation and to find new targets for the prevention and treatment of atrial fi-brillation.Methods:Collect the peripheral venous blood of the patients with rheumatic heart valve disease (total 46 patients,incude 24 with AF and 22 with SR).Use ELISA method to detect the Ang (1-7),AngⅡ concentrations in the serum samples.Then,analysis the difference and correlation between the two groups.Results:In the AF group,①the diameter of left atrium was significantly greater than the SR group(60.70±3.08&48.1 5±2.1 6mm,P<0.05);②the serum concentration of Ang (1-7)was significantly lower than that in the SR group(146.05 ± 1 7. 61&321.71±36.50 pg/ml,P <0.05);③the serum concentration of AngⅡ(45.88±2.87&35.78±1.08 pg/ml,P <0.05)were obviously higher than those in the SR group.Conclusion:For the patients with rheumatic valvular heart disease,the Ang (1-7)may weaken the function of AngⅡ,and by this way inhibits the atrial remodeling,and has a protective effect on the occurrence of atrial fibrillation.关键词
心脏瓣膜疾病/心房颤动/血管紧张素Ⅱ/Ang(1-7)Key words
Heart vale diseases/Atrial fibrillation/AngiotensinⅡ/Ang (1-7)分类
医药卫生引用本文复制引用
蒋永荣,张殿新,程功,潘军强,周鑫,武金娥,孙超峰..风湿性心脏瓣膜病患者血清 Ang（1-7）浓度与心房颤动的发生相关性分析∗[J].陕西医学杂志,2015,(8):994-995,2.基金项目
江苏省六大人才高峰基金（编号2011－WS 005）；南京市卫生局重点项目（编号ZKX 13022）；南京市卫生局课题 （）
