同位素Issue(3)：129-134,6.DOI:10.7538/tws.2015.28.03.0129
分光光度计法测量氨基聚醚的专属性
Specificity of the Spectrophotometry for Detecting Aminopolyether K2.2.2 in 18 F-FDG
摘要
Abstract
The residue of K2 .2 .2 was one of the key metric in 1 8 F-FDG quality control. The specificity of the spectrophotometry for K2 .2 .2 was compared with others.Methods:The 14 samples were determined for the K2 .2 .2 by the spectrophotometry and iodine-vapor TLC stain method,respectively.The results were compared with LC-MS/MS. The spectrophotometry showed that the 9 of negative samples were false positive ,2 of positive samples were higher than its actual K2 .2 .2 contents,3 of 1 8 F-FDG injections con-tained 14.3-1 9.2 μg/mL for K2 .2 .2 .The iodine-vapor TLC stain method showed that 9 of negative samples were negative,2 of positive samples were the same with its K2 .2 .2 contents,3 of 1 8 F-FDG injections were lower than 10 μg/mL with K2 .2 .2 .The iodine-vapor TLC stain results were confirmed by the LC-MS/MS.Results:The specificity of spectrophotometry was poor for K2 .2 .2 .The iodine-vapor TLC stain was simple and good specificity method for K2 .2 .2 in 1 8 F-FDG injections.关键词
分光光度计法/氨基聚醚/TLC/液质联用/专属性Key words
spectrophotometry/aminopolyether/TLC/LC-MS/MS/specificity分类
能源科技引用本文复制引用
张锦明,陈征宇,武向峰,张晓军,朱华,周明,杨志..分光光度计法测量氨基聚醚的专属性[J].同位素,2015,(3):129-134,6.基金项目
军队医疗机构制剂标准提高项目(14ZJZ21-1) （14ZJZ21-1）
