中国当代儿科杂志Issue(8)：786-791,6.DOI:10.7499/j.issn.1008-8830.2015.08.005
儿童初发IgA肾病肾病综合征型的临床特点
Clinical characteristics of children with an initial onset of IgA nephropathy with nephrotic syndrome
张良 1李志辉 1银燕 1段翠蓉 1寻劢 1吴天慧 1张翼 1丁云峰1
作者信息
- 1. 湖南省儿童医院/湖南省儿科医学研究所肾脏病研究室，湖南 长沙 410007
- 折叠
摘要
Abstract
ObjectiveTo study the clinical characteristics of children with an initial onset of IgA nephropathy with nephrotic syndrome and compare them with children with primary nephrotic syndrome, in order to provide a theoretical basis for the differential diagnosis of the two diseases.MethodsFifty children diagnosed with an initial onset of IgA nephropathy with nephrotic syndrome were included in this study. Seventy-two children diagnosed with an initial onset of primary nephrotic syndrome served as the control group. The clinical and laboratory examination characteristics were compared between the two groups.ResultsThe IgA nephropathy group had signiifcantly higher incidence rates of gross haematuria, microscopic haematuria, hypertension, acute kidney injury, low serum high-density lipoprotein cholesterol, anemia, low serum complement C4, steroid resistance, and nephritis-type nephrotic syndrome and a signiifcantly lower incidence of elevated serum IgE compared with the control group (P<0.05). There were signiifcant differences in serum creatinine, serum uric acid, serum total cholesterol, serum high-density lipoprotein cholesterol, serum IgE, serum complement C4, and hemoglobin levels between the IgA nephropathy and the control groups (P<0.05). The thresholds of serum IgE (<131.2 IU/mL) and high-density lipoprotein cholesterol (<1.35 mmol/L) were reference parameters in the differential diagnosis of IgA nephropathy with nephrotic syndrome and primary nephrotic syndrome. ConclusionsChildren with IgA nephropathy presenting nephrotic syndrome manifest mainly as nephritis type and steroid-resistant type in the clinical classiifcation.Cinical manifestations accompanied by serum levels of high-density lipoprotein cholesterol and IgE are helpful for differential diagnosis of IgA nephropathy presenting nephrotic syndrome and primary nephrotic syndrome.关键词
IgA肾病/肾病综合征/临床特点/儿童Key words
IgA nephropathy/Nephrotic syndrome/Clinical characteristics/Child引用本文复制引用
张良,李志辉,银燕,段翠蓉,寻劢,吴天慧,张翼,丁云峰..儿童初发IgA肾病肾病综合征型的临床特点[J].中国当代儿科杂志,2015,(8):786-791,6.
