中国当代儿科杂志Issue(8)：815-818,4.DOI:10.7499/j.issn.1008-8830.2015.08.011
婴幼儿喘息性社区获得性肺炎患儿血清炎症因子的变化
Changes in serum inflammatory factors in wheezing infants with community-acquired pneumonia
摘要
Abstract
ObjectiveTo study whether infantile wheezing pneumonia has similar immune mechanisms to asthma by determining the levels of serum inlfammatory factors in wheezing infants with community-acquired pneumonia (CAP). MethodsForty-two infants with CAP but without wheezing, 47 infants with CAP and wheezing, and 30 healthy infants as a control were recruited in the study. The peripheral blood levels of C-reactive protein, procalcitonin, soluble triggering receptor expressed on myeloid cell-l, interferon-γ, interleukin-4, interleukin-10, and periostin were compared in the three groups.ResultsThe serum levels of procalcitonin, soluble triggering receptor expressed on myeloid cell-l, interleukin-4 and interleukin-10 in the two CAP groups were higher than in the control group (P<0.05). The ratio of interferon-γ/interleukin-4 in the wheezing pneumonia group was lower than in the non-wheezing pneumonia and control groups (P<0.05). The serum level of periostin in the wheezing pneumonia group was higher than in the non-wheezing pneumonia and control groups (P<0.05).ConclusionsThe unbalanced ratio of interferon-γ/interleukin-4 and airway eosinophilic inlfammation in wheezing infants with pneumonia suggest infantile pneumonia with wheezing may has similar immune mechanisms to asthma.关键词
社区获得性肺炎/喘息/炎症因子/婴幼儿Key words
Community-acquired pneumonia/Wheezing/Inlfammatory factor/Infant引用本文复制引用
郁志伟,钱俊,顾晓虹,张晓娟,潘剑蓉,居慧莉..婴幼儿喘息性社区获得性肺炎患儿血清炎症因子的变化[J].中国当代儿科杂志,2015,(8):815-818,4.基金项目
无锡市社会发展计划指令性项目（CSE01N1109）。 （）
