中国当代儿科杂志Issue(8)：852-858,7.DOI:10.7499/j.issn.1008-8830.2015.08.018
预防性使用益生菌对降低极低出生体重早产儿坏死性小肠结肠炎发病率和病死率的Meta分析
Prophylactic probiotics for preventing necrotizing enterocolitis and reducing mortality in very low birth weight infants：a Meta analysis
摘要
Abstract
ObjectiveTo systematically evaluate the efficacy and safety of probiotic supplementation for preventing necrotizing enterocolitis (NEC) and reducing mortality in preterm very low birth weight (VLBW) infants. MethodsThe randomized controlled trials (RCTs) about probiotics for preventing NEC in preterm neonates were searched in PubMed, EMbase, Cochrane Central Register of Controlled Trials (CENTRAL), the ISI Web of Knowledge databases, China Biology Medicine disc (CBM), China National Knowledge Infrastructure (CNKI), Weipu and Wanfang Data from their establishment to March 2014. The Cochrane Collaboration's RevMan 5.1 Software was used for a Meta analysis.ResultsA total of 21 RCTs involving 4607 preterm VLBW infants were eligible for inclusion in the Meta analysis. The Meta analysis showed that probiotic supplement was associated with a signiifcantly decreased risk of NEC in preterm VLBW infants (RR=0.47; 95%CI: 0.35-0.62;P<0.001). Risk of mortality was also signiifcantly reduced in the probiotic group (RR=0.63; 95%CI: 0.51-0.78;P<0.01). Probiotic supplement did not decrease the risk for sepsis (RR=0.87;95%CI: 0.72-1.06;P=0.17) and NEC related mortality (RR=0.68; 95%CI: 0.31-1.48,P=0.33).ConclusionsThe results conifrm that probiotic supplement can reduce risk of NEC and mortality in preterm VLBW infants. However, the long-term effects and safety of probiotics need to be assessed in large trials.关键词
益生菌/坏死性小肠结肠炎/早产儿Key words
Probiotics/Necrotizing enterocolitis/Preterm infant引用本文复制引用
王小玲,李雄,康兰,王胜会,董文斌..预防性使用益生菌对降低极低出生体重早产儿坏死性小肠结肠炎发病率和病死率的Meta分析[J].中国当代儿科杂志,2015,(8):852-858,7.基金项目
泸州医学院院级资助项目（2013ZRQN014）。 （）
