中国感染控制杂志Issue(7)：468-475,8.DOI:10.3969/j.issn.1671-9638.2015.07.009
基层医院ICU与非ICU主要革兰阴性杆菌分布与耐药性差异
Distribution and antimicrobial resistance of maj or gram-negative bacilli in ICU and non-ICU wards in a grass-roots hospital
摘要
Abstract
Objective To investigate the distribution and antimicrobial resistance of major gram-negative bacilli isolated from patients in intensive care unit (ICU)and non-ICU wards,and provide reference for rational clinical antimicrobial appli-cation. Methods Specimen sources and antimicrobial resistance of gram-negative bacilli from hospitalized patients in ICU and non-ICU wards between 201 1 and 2013 were analyzed statistically and compared.Results A total of 3 875 gram-nega-tive bacterial isolates were detected among 25 153 specimens,isolation rate was 15.41% ;1 121 specimens from ICU were isolated 527 isolates of gram-negative bacilli,isolation rate was 47.01% ;3 348 isolates of gram-negative bacilli were isola-ted from 24 032 specimens of non-ICU,isolation rate was 13.93% ,there was significant difference between the two(χ2=899.32,P<0.001). Extended-spectrumβ-lactamases (ESBLs)-producing rate of Escherichiacoli and Klebsiellapneumon-iae in ICU patients was 56.00% (28/50)and 70.65% (65/92)respectively,in non-ICU patients was 52.81% (517/979) and 40.37% (241/597)respectively. The imipenem-resistant rate of Pseudomonas aeruginosa,Acinetobacterbaumannii, Escherichiacoli,and Klebsiellapneumoniae from ICU was 36.59% ,88.54% ,10.00% ,and 10.87% respectively,while from non-ICU was 20.21% ,61.15% ,1.74% ,and 2.85% respectively,the resistant rates of strains from ICU were high-er than non-ICU.Conclusion Antimicrobial resistant rates of major gram-negative bacilli from ICU are higher than those from non-ICU,and the main strains are multidrug-resistant non-fermentative bacteria. Clinical treatment should be different to reduce the emergence of drug-resistant bacteria.关键词
重症监护病室/普通病房/革兰阴性杆菌/抗药性,微生物/病原菌Key words
intensive care unit/general ward/gram-negative bacillus/drug resistance,microbial/pathogen分类
医药卫生引用本文复制引用
杜静,龙继川,李春辉..基层医院ICU与非ICU主要革兰阴性杆菌分布与耐药性差异[J].中国感染控制杂志,2015,(7):468-475,8.基金项目
湖南省科技计划项目 （）
