摘要
Abstract
Objective To explore the effect of formulated nutrients on bone mineral density and immunoglobulin level of breast-fed infants.Methods We enrolled 74 newborns in Maternal and Child Care Service Centre of Wuyi County .Using random number table method, the infants were divided into three groups: group A (n=25), group B (n=28) and group C (n=21) .The group A was fed with breast milk combined with formulated nutrients , the group B was purely fed with breast milk, and group C was fed with breast milk complemented with vitamin D .At birth, 6 months after and 12 months after, serum concentrations of 1, 25 (OH)2D3 and immunoglobulin (IgA, IgG, IgM) levels, T cell subsets (CD3 +、 CD4 +、 CD8 +) proportions and BMD level were detected and compared among the three groups .Results Group A was higher ( P<0.05 ) than group B and group C in 1, 25 (OH)2D3 serum concentration, levels of IgA, IgG and IgM, proportions of CD3 +and CD4 +T lymphocytes and BMD level 6 months and 12 months after birth.Group C was higher ( P <0.05 ) than group B in 1, 25 (OH)2D3 serum concentration, levels of IgA, IgG and IgM and proportions of CD3 +and CD4 +T lymphocytes 6 months after birth, and group C was higher ( P<0.05 ) than group B only in 1, 25 ( OH) 2 D3 serum concentration 12 months after birth; 6 and 12 months after birth, no significant difference was noted between group B and group C in BMD level (P>0.05). Gonclusion Infants fed with pure breast milk show lower BMD and vitamin level .Although the only supplement of Vitamin D can improve 1, 25 (OH)2D3 serum concentration in infants, its effect on bone mineral density and immunoglobulin level is relatively limited.Formulated nutrients could increase the immunoglobulin and BMD level and have a favorable application prospect .关键词
母乳喂养/婴儿/配方营养素/骨密度/免疫球蛋白亚类Key words
Breast feeding/Infant/Formulated nutrients/Bone mineral density/Immunoglobulin subunits分类
医药卫生
