Abstract
Objective To investigate the differences in the prognosis of recto -sigmoid cancer , rectal cancer and sigmoid cancer and the influencing factors .Methods We enrolled 354 patients with colorectal cancer in the Fourth Hospital of Hebei Medical University from January 2008 to December 2012.We collected the data of clinical features of the patients .From the day of surgery or pathological diagnosis , we conducted follow -up visits to patients and their families , and neoplasm recurrence , metastasis and death were considered as the outcome events respectively .PFS was defined as the time from diagnosis to the neoplasm recurrence , metastasis or death .All follow-up visits were ceased on January 1, 2014.Results Patients with the three kinds of neoplasms were significantly different in age , initial treatment method , the longest diameter of the tumor and the depth of infiltration (χ2 =0.009, 0.015, 0.019, 0.005; P<0.05).Of the 354 patients, we lost 17 patients with a loss rate of 4.8%;the follow-up time was 3 to 91 months, and the median follow -up time was 44 months.For the patients with recto-sigmoid cancer, the median survival time was 64.0 months 〔95%CI (47.5, 80.5)〕, and the survival rates of one year , two years and three years were 93.6%, 85.3%and 76.2%; for the patients with rectal cancer , the median survival time was 63.0 months 〔95%CI (53.2, 72.8)〕, and the survival rates of one year , two years and three years were 93.4%, 85.5%and 76.3%; for patients with sigmoid cancer , the median survival time was 63.0 months 〔95%CI (51.2, 74.8)〕, and the survival rates of one year , two years and three years were 94.5%, 87.2%and 79.3%.Patients with the three kinds of neoplasm were not significantly different in the survival curve (χ2 =1.246, P=0.536).The median PFS for patients with recto-sigmoid neoplasm, rectal neoplasm and sigmoid neoplasm was 48.0 months 〔95%CI (36.3, 59.7)〕, 29.0 months 〔95%CI (17.9, 40.1)〕 and 63.0 months 〔95%CI (37.1, 88.9)〕 respectively.Patients with the three kinds of neoplasm were significantly different in PFS survival curve (χ2 =17.329, P=0.001).Cox regression analysis showed that the neoplasm site〔HR=0.585, 95%CI (0.338, 0.891), P=0.012〕 and depth of infiltration 〔HR=3.516, 95%CI (1.883, 6.746), P=0.038〕 were independent predictive factors for PFS of patients with colorectal cancer .Conclusion There are no differences in survival time among patients with recto -sigmoid neoplasm , rectal neoplasm and sigmoid neoplasm , while differences exist in PFS.The depth of infiltration may be the influencing factor for PFS of patients with colorectal cancer .关键词
结肠肿瘤/乙状结肠肿瘤/直肠肿瘤/预后Key words
Colonic neoplasms/Sigmoid neoplasms/Rectal neoplasms/Prognosis分类
医药卫生
