中国全科医学Issue(24)：2881-2884,2885,5.DOI:10.3969/j.issn.1007-9572.2015.24.002
复发及病程对抑郁症患者心率变异性的影响研究
Influence of Relapse and Disease Duration on Heart Rate Variability of Patients With Depressive Disorder
摘要
Abstract
Objective To compare heart rate variability ( HRV) between patients with first -episode depression and patients with recurrent depression and investigate the influence of relapse and disease course of depression on HRV .Methods We recruited 81 depressive patients with payment from Wuxi Mental Health Center from October 2012 to September 2014.These patients were divided into two groups: first -episode group (n=35) and recurrent group (n =46).We also recruited 43 healthy people with payment and assigned them into control group . Clinical data of subjects were collected; 24 h dynamic electrocardiogram was undertaken , and HRV was analyzed; analysis of covariance was conducted to compare SDNN , pNN50, LF and HF among the three groups; partial correlation analysis was conducted to determine the correlation between disease duration of depression and HRV indicators .Results The first-episode group had shorter disease duration than the recurrent group (P<0.05).The test on interaction effect showed that HRV indicators all satisfied the parallelism hypothesis of covariance analysis (SDNN: Finteraction =1.234, Pinteraction =0.301; pNN50: Finteraction =0.382, Pinteraction =0.766; LF: Finteraction =1.243, Pinteraction =0.297; HF: Finteraction =1.071, Pinteraction =0.364).The three groups were not significantly different (P>0.05) in LF and HF; the three groups were significantly different ( P <0.05 ) in SDNN and pNN50; the first -episode group and recurrent group were lower (P<0.05) than the control group in SDNN and pNN50, and the recurrent group was lower (P<0.05) than the first -episode group in SDNN.The partial correlation analysis on depressive patients ( first -episode and recurrent group) with age, BMI, HAMA score and HAMD score as the control variables showed the following results: ( R=-0.372, -0.261; P=0.001, 0.022) and marginally negatively correlated with pNN50 (R=-0.224, P=0.050) and had no linear correlation with LF (R=-0.076, P=0.513).Conclusion Depressive patients have low HRV .Patients with recurrent depression have lower HRV than patients with first -episode depression , and disease duration was negatively correlated with SDNN and HF.The lapse of depression and longer disease duration may aggravate autonomic nerve function disorder .关键词
抑郁症/复发/病程/心率变异性Key words
Depressive disorder/Recurrence/Disease duration/Heart rate variability分类
医药卫生引用本文复制引用
王军,朱文娴,柳艳松,张付全,周振和..复发及病程对抑郁症患者心率变异性的影响研究[J].中国全科医学,2015,(24):2881-2884,2885,5.基金项目
南京医科大学科技发展基金面上项目 （）
