中国药房Issue(22)：3122-3124,3.DOI:10.6039/j.issn.1001-0408.2015.22.30
猫爪草滴丸的制备工艺优化
Optimization of the Preparation Technology of Ranunculi ternati Radix Dropping Pills
摘要
Abstract
OBJECTIVE:To optimize the preparation technology of Ranunculi ternati radix dropping pills and evaluate the qual-ity. METHODS:Based on single factor test,with the overall score of the appearance,weight difference and dissolution time of the dropping pills as the evaluated index,orthogonal test design was adopted to investigate 4 factors such as weight ratio of substrate to drugs dry extract,temperature of condensation medium,dropping rate and dropping distance which would affect the molding tech-nology of Ranunculi ternati radix dropping pills,to optimize the preparation technology of Ranunculi ternati radix dropping pills, and verification tests and quality investigation were carried out. RESULTS:The optimal molding technology was as follows as the weight ratio of drugs dry extract to substrate (polyethylene glycol 6000) of 1∶1.5,the temperature of condensation medium (si-methicone)of 8℃,dropping rate of 40 drops/min,dropping distance of 150 mm. The overall scores of the dropping pills by 3 ver-ification tests were 94.05,93.78 and 94.12 (RSD<3%,n=3) respectively. The dropping pills prepared by the above-mentioned technology had good round appearance,appropriate hardness and uniform color. The average weight of pills was 60 mg,dissolu-tion time was 5 min and the content of polysaccharides in each Ranunculi ternati radix dropping pill was 20.20 mg. CONCLU-SIONS:The optimal preparation technology of Ranunculi ternati radix dropping pills is simple and feasible with good reproducibili-ty.关键词
猫爪草/滴丸/制备工艺/正交试验/优化/质量评价Key words
Ranunculi ternati radix/Dropping pills/Preparation technology/Orthogonal test/Optimization/Quality evaluation分类
医药卫生引用本文复制引用
陈琼,李娟,李阳,杨俊杰,余红霞..猫爪草滴丸的制备工艺优化[J].中国药房,2015,(22):3122-3124,3.基金项目
河南省科技攻关项目 （）
