中国药房Issue(23)：3220-3222,3.DOI:10.6039/j.issn.1001-0408.2015.23.17
宫颈癌患者顺铂化疗疗效与RAD51基因多态性的关系
Relationship between RAD51 Polymorphism and Therapeutic Efficacy of Cisplatin Chemotherapy in Cervical Cancer Patients
吴小春 1吕贤贞 1章亚文1
作者信息
- 1. 兰溪市妇幼保健院妇产科，浙江金华 321100
- 折叠
摘要
Abstract
OBJECTIVE:To observe the effects of RAD51 gene polymorphism on cancer prognosis and its relationship with therapeutic efficacy of cisplatin chemotherapy in patients with cervical cancer. METHODS:193 cervical cancer patients were selected and genotyped by TaqmanTM genotyping method. Therapeutic efficacy and survival period were observed in cisplatin chemotherapy combined with radiotherapy. RESULTS:The mean survival rate and therapeutic efficacy was significantly correlated with RAD51 genotype. The patients carrying the T gene had better response to drugs,compared to patients with type GG (P<0.05),and the average survival rate significantly increased(P<0.05). CONCLUSIONS:Genetic variation in RAD51 have obvious influence on the prognosis of cervical cancer chemotherapy. Therefore,RAD51 G172T genotypes give effective prognosis information about cervical cancer patients who received cisplatin chemotherapy.关键词
宫颈癌/顺铂/RAD51基因多态性Key words
Cervical cancer/Cisplatin/RAD51 polymorphism分类
医药卫生引用本文复制引用
吴小春,吕贤贞,章亚文..宫颈癌患者顺铂化疗疗效与RAD51基因多态性的关系[J].中国药房,2015,(23):3220-3222,3.
