中国药理学通报Issue(8)：1037-1039,1040,4.DOI:10.3969/j.issn.1001-1978.2015.08.001
miRNAs对药物代谢酶的转录后调控
Post-transcription regulation of drug metabolic enzymes by miRNAs
摘要
Abstract
microRNAs ( miRNAs) are a family of short non-cod-ing RNAs that regulate the expression of target genes by binding to complementary regions. The miRNAs expression is readily al-tered by drugs, carcinogens, hormones, stress or diseases, and that might lead to changes in the drug metabolism, pharmacoki-netics or potency. Moreover, the evaluation of drug metabolic enzyme-related miRNAs would provide useful information for per-sonalized medicine. This review describes the current knowledge on the post-transcription regulation of drug metabolic enzymes by miRNAs.关键词
miRNAs/代谢酶/CYP450/UGT/GST/转录后调控Key words
miRNA/metabolic enzymes/CYP450/UGT/GST/post-transcription regulation分类
医药卫生引用本文复制引用
王沛,李晓天,张莉蓉..miRNAs对药物代谢酶的转录后调控[J].中国药理学通报,2015,(8):1037-1039,1040,4.基金项目
国家自然科学基金资助项目(No 81173127) （No 81173127）
