中国药业Issue(15)：16-16,17,2.
前列地尔治疗重症急性胰腺炎肝损害临床研究
An Clinical Study on Protective Effects of Prostaglandin on Liver Injury Caused by Severe Acute Pancreatitis
王伟 1何显炬 1熊盟1
作者信息
- 1. 南昌大学第二附属医院，江西 南昌 330006
- 折叠
摘要
Abstract
Objective To observe the protective effects of prostaglandin on liver injury caused by severe acute pancreatitis ( SAP ) . Methods Thirty - one SAP patients with liver injury were randomly divided into controlgroup. ( n = 15) and testgroup ( n = 16). Patients in controlgroup were treated with routine method, and patients in testgroup were treated with routine method plus prostaglandin injec-tion. the levels of serum alanine aminotransferase (ALT), aspartate aminotransferase(AST), glutamyl transferase (GGT), total bilirubin (TBIL), Albumin(ALB), were measured by automatic biochemistry analyzer. C - Reactive protein(CRP) were measured by particular pro-tein analyzer. Results The Plasma levels of ALT, AST, GGT, TBIL decreased in both group after admission, but the extent of reduction in testgroup was significantly higher than that in group controlgroup( P < 0. 05) . the level of TLB in controlgroup patients with SAP was significantly lower than that in testgroup after treatment 2 weeks later( P < 0. 05). The extent of reduction Plasma levels of CRP in testgroup was significantly higher than that in group controlgroup 1 week later( P < 0. 05) . Conclusion prostaglandin can play a protective role in liver injury caused by SAP.关键词
胰腺炎/肝损害/前列地尔/血清丙氨酸氨基转移酶/天冬氨酸氨基转移酶/谷氨酰基转移酶/总胆红素/白蛋白/C 反应蛋白Key words
pancreatitis/liver injury/alprostadil/alanine aminotransferase(ALT)/aspartate aminotransferase(AST)/glutamyl transferase (GGT)/total bilirubin (TBIL)/Albumin (ALB)/C - Reactive protein(CRP)分类
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王伟,何显炬,熊盟..前列地尔治疗重症急性胰腺炎肝损害临床研究[J].中国药业,2015,(15):16-16,17,2.
