中国药业Issue(15)：19-20,21,3.
复方利多卡因乳膏体外透皮研究
In Vitro Percutaneous Characteristics of Compound Lidocaine Cream
贺亚静 1武学鑫 2周洁 3沈腾 1贺吉香2
作者信息
- 1. 山东中医药大学药学院，山东 济南 250355
- 2. 复旦大学药学院药剂学教研室，上海 201203
- 3. 山东宏济堂制药集团有限公司，山东 济南 250355
- 折叠
摘要
Abstract
Objective To investigate in vitro percutaneous characteristics of compound lidocaine cream, and the consistenty of in - vitrope-rcutaneous with the Emla cream. Methods The concentration of lidocaine and prilocaine in receptor fluid was quantified by HPLC. The in - vitro percutaneous experiments of compound lidocaine cream through rat abdomen skin were perfromed by modified Franz′s cell. Results There were good linear relationship between the peak area and concentration in the range of 0. 224 - 16. 8 μg / mL for lidocaine, andin the range of 0. 192 - 14. 414 μg / mL for prilocaine. The accuracy and precision could meet the require-ments. Percutaneous characteristicsof lidocaine and prilocaine accord with zero order kinetics equation. The flux oflidocainefor test and control creamis (274. 6 ± 30. 25) μg / (cm2·h)and (266. 4 ± 21. 56 )μg / (cm2·h), and the flux ofprilocainefor test and control creamis (314. 2 ± 31. 08)μg / (cm2 ·h) and (309. 4 ± 23. 08) μg / (cm2 ·h) There were no significant difference( P > 0. 05) by t - test statis-tics. Conclusion In vitropercutaneous patternare consistent for test and control compound lidocaine creams.关键词
利多卡因/丙胺卡因/高效液相色谱法/体外透皮试验Key words
lidocaine/prilocaine/HPLC/in vitro percutaneous experiments分类
医药卫生引用本文复制引用
贺亚静,武学鑫,周洁,沈腾,贺吉香..复方利多卡因乳膏体外透皮研究[J].中国药业,2015,(15):19-20,21,3.
