中国药业Issue(15)：21-22,23,3.
甲巯咪唑单室三层（夹芯）渗透泵制剂的制备
Preparation of Single Room Three Layers (Sandwich)Pump Tablets of Thiamazole
宋岐 1赵明明 1金洋 1杨悦婧 1金向群 1路海滨1
作者信息
- 1. 吉林大学药学院，吉林 长春 130021
- 折叠
摘要
Abstract
Objective A sulfhydryl imidazole (thiamazole) as the model drug research easily soluble drug single room three layer prepa-ration of osmotic pump tablets. Methods To the main drug a sulfhydryl imidazole and HPMC mixed layer of core making drugs, with ethyl cellulose and HPMC mixed up and down two floors. Formulation and outsourcing and the slice of core layer prescription proportion optimization; With similarity factor method to investigate the in vitro release condition. Results Drug core layer of the best combination is a imidazole 10 mg and HPMC K15 m 60 mg, up and down the parcel layer are HPMC K100 m 30 mg and 10 mg ethyl cellulose. The release medium and speed had no significant effect on drug release. Conclusions The osmotic pump tablets preparation is simple, can well control the a sulfhydryl imidazole 8 h drug release at a constant speed. sandwich osmotic pump tablet was relieved from the cumbersome process, such as coating and stiletto reduce a lot of process, the preparation process is simple.关键词
甲巯咪唑/单室三层渗透泵片/易溶性药物/控制释放/相似因子Key words
thiamazole/single room three layers (sandwich) pump tablets/easily soluble drugs/controlled release/similarity factor分类
化学化工引用本文复制引用
宋岐,赵明明,金洋,杨悦婧,金向群,路海滨..甲巯咪唑单室三层（夹芯）渗透泵制剂的制备[J].中国药业,2015,(15):21-22,23,3.
