中国药业Issue(15)：101-102,103,3.
依帕司他联合甲钴胺治疗糖尿病周围神经病变40例
Clinical Observation on Therapeutic Effects of Treatment of Diabetic Peripheral Neuopathy with Epalrestat Combination Methycobal in 40 Cases
李桃荣 1宁尚侠1
作者信息
- 1. 华中科技大学同济医学院附属荆州医院，湖北 荆州 434020
- 折叠
摘要
Abstract
Objective To evaluate the clinical efficacy of epalrestat and Methycobal combined therapy in treating diabetic peripheral neuropathy(DPN) . Methods 80 cases of peripheral neuropathy and type 2 diabetes were randomly separated into an experiment group and a control group, 40 cases of each group. The normal treatment of diabetes was used in two groups, members in the experiment group were treated with methycobal 500 μg, 3 times one day. and epalrestat 50 mg, 3 times one day; members in the control group were treat-ed with methycobal 500 μg, 3 times one day. At the end of 12 weeks, therapeutic courses, motor nerve conduction velocity (MNCV) and sural nerve conduction velocity(SNCV) were evaluated. Results The overall effective rate was 92. 50% in the experiment group and 72. 50% in the control group, showing significant different between the two groups( P < 0. 05) . The post therapeutic values of both SNCV and MNCV were significantly difference from those of previous treatment( P < 0. 01 ) . No evidently relative adverse effects were observed in both groups. Conclusion Combined therapy of epalrestat and Methycobal was more effective in controlling the clinical ac-tivity to diabetic peripheral neuropathy.关键词
糖尿病周围神经病变/依帕司他/甲钴胺Key words
diabetic peripheral neuropathy/epalrestat/methycobal分类
医药卫生引用本文复制引用
李桃荣,宁尚侠..依帕司他联合甲钴胺治疗糖尿病周围神经病变40例[J].中国药业,2015,(15):101-102,103,3.
