中国中西医结合外科杂志Issue(4)：376-379,4.DOI:10.3969/j.issn.1007-6948.2015.04.012
乳香提取物抑制裸鼠胰腺癌生长的作用及机制研究
The Inhibitory Effect and Mechanism of Pancreatic Cancer in Nude Mice Model with Frankincense Ex-tract
倪效 1梁晓强 1张静喆1
作者信息
- 1. 上海中医药大学附属龙华医院普外科 上海 200032
- 折叠
摘要
Abstract
Objective To investigate the inhibitory effect and mechanism of pancreatic cancer in nude mice model with Frankincense extract. Methods MIA PaCa-2 of pancreatic cancer cell lines were implanted into nude mice subcutaneously .The nude mice were randomly assigned to receive either PBS(control) or Frankin⁃cense extract injection subcutaneously (the number of treatment group was 6, while the control group was 5). Af⁃ter 12 days, tumors were removed . Tumor volume were mersured. Tumors were fixed and immunohistochemical analysis for PHH3 and TUNEL. Results The tumor size of the treatment group was (76.67 ± 24.11) mm3 while the control group was(204.80±101.19)mm3. The difference is statistically significant (p < 0.05). The number of PHH3-immunoreactive cells of treatment group was (197.5±40.4), while the control group was (252.8±30.6). The difference is statistically significant (P<0.05). The number of TUNEL positive cells in treatment group was (316.7 ± 117.3), while the control group was (100.6 ± 47.2). The difference is statistically significant (P<0.05). Conclusion The Frankincense extract can inhibit the growth of pancreatic cancer in vivo of xenograft murine.关键词
乳香/胰腺癌/凋亡/裸鼠Key words
Frankincense/pancreatic cancer/apoptosis/nude mice分类
生物科学引用本文复制引用
倪效,梁晓强,张静喆..乳香提取物抑制裸鼠胰腺癌生长的作用及机制研究[J].中国中西医结合外科杂志,2015,(4):376-379,4.
