摘要
Abstract
Objective To investigate the etiology classiifcation features and related risk factors of ischemic stroke in young adults. <br> Methods We retrospectively analyzed the clinical data of 120 successive patients with ifrst-ever ischemic stroke in young adults from January 2010 to June 2014 in the Department of Neurology, Beijing Haidian Hospital as young patient group. And 136 middle-aged and old patients with ischemic stroke were selected randomly as control group. The clinical data of all the subjects were collected. The study was to identify the etiology classification and related risk factors in whole cohort, and further to compare the difference between the two groups in above characteristics based on China Ischemic Stroke Subclassiifcation (CISS). <br> Results There were 82 (68.3%) male and 38 (31.7%) female in young ischemic stroke group. There were 76 (55.9%) male and 60 (44.1%) female in the control group. Male stroke incidence in the young group was significantly higher than in the elderly group (χ2=4.183,P=0.041). The CISS classification in young patient group was as follows: large artery atherosclerotic (LAA)25.8%, stroke of other undetermined etiology (SUE) 22.5%, perforating branch artery occlusion (PAO) 20.8%, cardioembolism (CE) 19.2%, stroke of other etiology (SOE) 11.7%. Middle-aged and old patient group showed LAA 40.5%, PAO 33.8%, CE 21.3%, SOE 2.9%, SUE 1.5%. LAA, PAO, SOE, SUE between the two groups were significantly different except CE (P<0.05). The youth group SOE, SUE etiology classification was obviously higher than in the control group, and the difference was significant (P<0.05). Young ischemic stroke risk factors of the top 5 are smoking 48.3%, hypertension 44.2%, hyperlipidemia 40.8%, alcohol drinking 36.7%, family history of stroke 23.3%. In contrast, the middle-aged stroke group is hypertension 57.4%, diabetes 47.1%, hyperlipidemia 43.4%, carotid atherosclerosis 37.5%, smoking 35.3%. Comparison of risk factors between the two groups, young group, smoking, drinking and family history of stroke was signiifcantly higher than that in the middle-aged and old group.There was signiifcant difference between two groups (P<0.05). <br> Conclusion Young ischemic stroke etiology classiifcation characteristics and related risk factors differ from the middle-aged and old patients. Early etiological classiifcation and detection of risk factors are beneifcial to the prevention and treatment for ischemic stroke in young adults.关键词
缺血性卒中/青年/病因分型/危险因素Key words
Ischemic stroke/Young adults/Etiology classiifcation/Risk factors
