磁共振成像Issue(8)：561-565,5.DOI:10.3969/j.issn.1674-8034.2015.08.001
积极开展定量动态增强磁共振成像研究
An expectable wave of clinical studies using quantitative dynamic contrast-enhanced MR imaging
摘要
Abstract
AbstractQuantitative dynamic contrast-enhanced MR imaging (dynamic contrast-enhanced MRI, DCE-MRI) using fast T1-weighted imaging is considered as a functional tool to non-invasively assess the microcirculation features of normal or diseased tissues. It can be used to assess tissue perfusion and microvessel permeability by means of qualitative, semi-quantitative and quantitative method. With inclusion of arterial input function and tissue concentration of contrast agents used, quantitative DCE-MRI is superior to either qualitative or semi-quantitative method with respect to accurate evaluation of tissue perfusion and microvessel permeability; and can avoid inconsistent analysis results between different researchers caused by individual scanning protocols used. Thus quantitative DCE-MRI is not only favorable to achieve an early diagnosis and improve accuracy of the differential diagnosis of various disease entities, but also helpful for implementation of a multicenter randomized control clinical trials to obtain evidence medicine data. To date, some obstacles are still present in DCE-MRI, such as the standardization of scanning protocols and data computation, particularly the application of appropriate hemodynamic models. Advanced software specialized designed for quantitative DCE-MRI can provide a standard and convenient platform for data analysis. With the help of such favorable platform, the progress of clinical application of DCE-MRI would be promoted and its application ifeld would be extended.关键词
磁共振成像/动态增强/定量分析Key words
Magnetic resonance imaging/Dynamic contrast-enhancement/Quantitative analysis分类
医药卫生引用本文复制引用
沈君..积极开展定量动态增强磁共振成像研究[J].磁共振成像,2015,(8):561-565,5.基金项目
教育部新世纪优秀人才支持计划(编号NCET-11-0538) （编号NCET-11-0538）
