磁共振成像Issue(8)：566-570,5.DOI:10.3969/j.issn.1674-8034.2015.08.002
DCE-MRI在高、低级别脑胶质瘤及脑膜瘤中的鉴别诊断
Dynamic contrast-enhanced MRI in the differential diagnosis of high grade glioma, low grade glioma and meningioma
摘要
Abstract
AbstractObjective:Through undergoing dynamic contrast-enhanced MRI (dynamic contrast-enhanced MRI, DCE-MRI) before operation to provide quantitative basis for the differential diagnosis of the three kinds of tumors.Materials and Methods:Nineteen cases of gliomas (7 with low grade, 12 with high grade) and 19 cases of meningiomas (13 with benign, 6 with malignant or anaplastic) were enrolled. The pharmacokinetic model of Extended Tofts Linear was used to calculate the datas, the tissue enhancement-time curve and pharmacokinetic parameters (volume transfer constant, Ktrans, extracellular extravascular volume fraction, Ve; and blood plasma fraction, Vp) of the lesion, solid components were obtained. Ktrans value, Ve value and Vp value were compared to judge whether there were signiifcant differences between the three kinds of tumors.Results:The values of Ktrans and Ve in high grade glioma (HGG) were signiifcantly higher than the low grade glioma(LGG) (P<0.05); Vp values of high grade glioma were slightly higher than the low grade glioma, but the difference was not statistically signiifcant; The values of Ktrans and Ve in meningiomas were signiifcantly higher than the low grade gliomas (P<0.05), but the difference of Vp values were not statistically significant; the differences of Ktrans, Ve, Vp of gliomas and meningiomas were not statistically significant (P>0.05).Conclusion:DCE-MRI can effectively distinguish low grade glioma from high grade glioma and low grade glioma from meningioma, At the same time, DCE-MRI improves the diagnosis accuracy of glioma and invasive meningioma through the quantitative analysis .关键词
磁共振成像/动态增强/脑胶质瘤/脑膜瘤/渗透参数Key words
Magnetic resonance imaging/Dynamic contrast-enhancement/Glioma/Meningioma/Pharmacokinetic parameters分类
医药卫生引用本文复制引用
张微,牛蕾,马敏阁,周好,刘学军,冯卫华,隋庆兰..DCE-MRI在高、低级别脑胶质瘤及脑膜瘤中的鉴别诊断[J].磁共振成像,2015,(8):566-570,5.基金项目
青岛市科技局民生项目(编号14-2-3-7-nsh) （编号14-2-3-7-nsh）
