重庆医学Issue(22)：3055-3057,3.DOI:10.3969/j.issn.1671-8348.2015.22.011
肝癌患者高表达神经细胞黏附分子 L1预后差
High level of L1CAM predicting poor prognosis in hepatocellular carcinoma patients
杨少芬 1池秀芳2
作者信息
- 1. 广州医科大学卫生职业技术学院基础医学部病理教研室，广州 510925
- 2. 广东省妇幼保健院新生儿科，广州 510010
- 折叠
摘要
Abstract
Objective To investigate the clinical significance and prognostic value of PKD3 expression in human hepatocellu-lar carcinoma (HCC)after hepatectomy.Methods We analyzed mRNA expression of L1CAM in 1 10 HCCs by quantitative real-time PCR (qRT-PCR)and western blot,and the relationship among the overall survival of HCCs.Results The relative protein and mRNA expression level of L1CAM was up-regulated in HCCs comparing with adjacent non tumor liver tissues (P <0.01).L1CAM expression in the well-differentiated group was higher than that in the poor-differentiated group (P < 0.01 ).The expression of L1CAM mRNA was significantly correlated with tumor differentiation and TNM stage (P <0.05).The prognosis of patients with high expression L1CAM was poor (P <0.01).Conclusion L1CAM expression is related to occurrence and development of HCCs and may predict the prognosis of HCCs after hepatectomy.关键词
癌,肝细胞/神经细胞黏附分子L1/预后Key words
carcinoma,hepatocellular/neural cell adhesion molecule L1/prognosis分类
医药卫生引用本文复制引用
杨少芬,池秀芳..肝癌患者高表达神经细胞黏附分子 L1预后差[J].重庆医学,2015,(22):3055-3057,3.
