重庆医学Issue(23)：3210-3212,3215,4.DOI:10.3969/j.issn.1671-8348.2015.23.013
INS 基因遗传多态性与2型糖尿病发病风险及血清 IAA-Ab 水平相关性研究∗
Study on relationship among INS genetic polymorphismsms and the occurrence of type 2 diabetes and serum IAA-Ab levels
摘要
Abstract
Objective To investigate the relationship between polymorphisms of gene promoter region INS 5′UTR single nu-cleotide and type 2 diabetes and serum IAA-Ab levels.Methods By Sequenom MassArray SNP genotyping detection technology, INS 3 pyomter regime single nucleotide polymorphisms (rs689,rs714641 77 and rs3842738)of 497 patients in Chongqing with type 2 diabetes cases(treatment group)and 500 cases(control group)were genotyped and analyzed.IAA-Ab levels in diabetes patients was detected.Theχ2 test statistic was used to analyze the treatment group and control groups.The genotype frequency distribution of IAA-Ab-positive and negative groups SNP was analyzed by non-conditional logistic regression,adjusted for sex,age impact,cal-culated the odds ratio (OR)and 95 % confidence interval(CI ).The polymorphic loci with type 2 diabetes susceptibility and serum GAD-Ab levels was evaluated.Results The genotype frequency distribution of rs689AA,TT and AT was 58.75%,28.77% and 12.47%,respectively.The control group are 50.40%,35.60% and 14.00% respectively.The difference was statistically significant (χ2 =3.923,P <0.05).Compared with the genotype of AA,TT genotype can decrease risky of diabetes,with OR values 0.35(95%CI :0.18-1.06).There was significant difference of AA,TT,AT genotypes between IAA-Ab negative and IAA-Ab positive pa-tients (P < 0.05 ).Conclusion INS polymorphisms might be related to the risky of type 2 diabetes and serum IAA-Ab level in chinses population.关键词
糖尿病,2 型/多态性,单核苷酸/IAA-Ab/INS 基因Key words
diabetes mellitus,type 2/polymorphism,single nucleotide/IAA-Ab/INS gene分类
医药卫生引用本文复制引用
李泉,董姗姗,乔正荣,刘钉宾,曾建涛,张吉,柏艳,向勤,胡渠,吴逊..INS 基因遗传多态性与2型糖尿病发病风险及血清 IAA-Ab 水平相关性研究∗[J].重庆医学,2015,(23):3210-3212,3215,4.基金项目
重庆市卫生局科研资助项目(2011-2-469)。 （2011-2-469）
