重庆医学Issue(23)：3236-3238,3241,4.DOI:10.3969/j.issn.1671-8348.2015.23.023
复方槲皮素乳膏的制备和质量控制∗
Preparation and quality control of compound quercetin creams
摘要
Abstract
Objective To study the preparation of quercetin compound cream and establish its standard of quality control. Methods The composition of recipe and manufacturing technique were designed.The content of components were determined by HPLC,and its stability tests were carried out.Results The product was a kind of yellow smooth cream.The linear ranges were 0.053-1.696 μg for quercetin(r=0.999 9),0.053-1.696 μg for 8-methoxypsoralen(r=0.999 8)and 0.100-1.000 μg for beta-methasone(r=0.999 9).The average recovery rate were 99.83%,99.52%,and 99.74% of quercetin,8-methoxypsoralen,and beta-methasone(n=9).After 12 months′long term stability test,all the 3 batches of sample preparations were in line with relevant regu-lations.Conclusion The designed recipe was reasonable,and the manufacturing technique was feasible,with stable and controllable quality.关键词
槲皮素/倍他米松/8-甲氧补骨脂素/制备/质量控制Key words
quercetin/betamethasone/8-methoxypsoralen/preparation/quality control分类
医药卫生引用本文复制引用
魏传梅,胡丽敏,樊其忠,孙绍伟,高培民..复方槲皮素乳膏的制备和质量控制∗[J].重庆医学,2015,(23):3236-3238,3241,4.基金项目
滨州市科技发展计划(2013ZC1801)。 （2013ZC1801）
