重庆医学Issue(24)：3341-3344,4.DOI:10.3969/j.issn.1671-8348.2015.24.010
广西汉族人群 NPC1L1基因1735 C>G 多态性分布特征及与血脂、肥胖的关系∗
Distribution characteristics of NPC1L1 gene 1 735 C>G polymorphism and relationship between serum lipid levels and obesity in Guangxi Han population
摘要
Abstract
Objective To analyze the distributional characteristics of NPC1L1 1 735 C>G polymorphism and the relation-ship between serum lipid levels and obesity in Guangxi Han population.Methods Genotyping of the NPC1L1 1 735 C>G poly-morphism of 409 cases of Han was performed by polymerase chain reaction and restriction fragment length polymorphism combined with gel electrophoresis in all subjects.The relationship of different genotypes in blood lipid levels and obesity were evaluated.Re-sults The frequency of CC,CG and GG genotypes was 39.40%,46.00% and 14.60% in Han.The frequency of C and G alleles was 62.35% and 37.65% in Han.The levels of BMI,LDL-C,ApoB was different among the three genotypes (P <0.05).The G al-lele carriers had higher serum LDL-C and ApoB levels than the G allele noncarriers (P <0.05 ).Serum lipid parameters and BMI were also correlated with some environmental factors.Conclusion The 1 735 C>G polymorphism in NPC1L1 gene may be correla-ted with serum lipid profiles and obesity,the G allele might increase the risk of hyperlipemia and obesity.关键词
多态性,单核苷酸/血脂异常/NPC1L1/人体质量指数Key words
polymorphism,single nucleotide/dyslipidemias/niemann-pick c1-like 1/body mass index分类
医药卫生引用本文复制引用
苗林,尹瑞兴,吴东峰..广西汉族人群 NPC1L1基因1735 C>G 多态性分布特征及与血脂、肥胖的关系∗[J].重庆医学,2015,(24):3341-3344,4.基金项目
国家自然科学基金资助项目(30960130)。 （30960130）
