重庆医学Issue(24)：3389-3392,4.DOI:10.3969/j.issn.1671-8348.2015.24.026
代谢综合征与结肠癌关系的 Meta 分析
Metabolic syndrome and colon cancer:a Meta-analysis
雷平平 1何伟平 1石泉 1吴彩云 1王高明 1陈建慧 1孙志刚1
作者信息
- 1. 南昌大学第五附属医院心血管内科，江西抚州 344000
- 折叠
摘要
Abstract
Objective To investigate the association between Metabolic syndrome and colon cancer.Methods A literature search was performed through PubMed,Ovidsp,CNKI and Wangfang Data within the time limit of January 1 990 to May 2014.Ac-cording to the inclusion and exclusion criteria,the studies were screened and the data were extracted.Then Meta-analysis was per-formed using Stata Statistical Software version 12.0.Results A total of 8 studies(6 cohort studies and 2 case-control studies)met the inclusion criteria.Meta analysis showed that patients with Metabolic syndrome had a higher risk of colon cancer incidence com-pared with the control group without Metabolic syndrome(OR =1.43,95%CI :1.23 - 1.66,P <0.05 ).Stratified analysis showed Metabolic syndrome had a higher risk of colon cancer incidence in male(OR=1.50,95%CI :1.22-1.84,P <0.05),but in female, this association was not found(OR=1.39,95%CI :0.98- 1.96,P =0.07).In addition,Meta analysis showed that Metabolic syn-drome was not associated with an increased risk of colon cancer mortality(OR=1.22,95%CI :0.92-1.63,P =0.1 7).Conclusion This Meta analysis indicated a positive association between Metabolic syndrome and colon cancer incidence in male,but not in fe-male.Metabolic syndrome might not be associated with an increased risk of colon cancer mortality,yet it needs more prospective co-hort studies to confirm the conclusion.关键词
代谢综合征/结肠癌/Meta 分析Key words
metabolic syndrome/colon cancer/Meta analysis分类
医药卫生引用本文复制引用
雷平平,何伟平,石泉,吴彩云,王高明,陈建慧,孙志刚..代谢综合征与结肠癌关系的 Meta 分析[J].重庆医学,2015,(24):3389-3392,4.
