吉林医药学院学报Issue(5)：328-330,3.
可乐对小鼠精子畸形及睾丸酶的影响
Effect of cola on mouse sperm malformation and testicular enzyme
张岚 1曹发正 1刘彦麟 1王齐1
作者信息
- 1. 吉林医药学院公共卫生学院，吉林 吉林 132013
- 折叠
摘要
Abstract
Objective To investigate the effect of cola on sperm abnormality and testicular enzyme levels and discov-er the damage of cola on male reproductive system. Methods 60 male mice were randomly divided into 5 groups. The mice in dministration group were gavaged with 2 times,4 times and 8 times cola by 20 mL/( kg·d) dose for 35 days,negative control group was gavaged with 20 mL/( kg·d) saline for 35 days,positive control group was given 20 mL/( kg·d) cyclophosphamide orally for 9 days. The mice were sacrificed by cervical mortar method, sperm speci-mens were used to observe abnormal sperms, testicular lactate dehydrogenase ( LDH ) and alkaline phosphatase ( ALP) activities were measured by colorimetry. Results Sperm malformation rate of the administration groups were significantly higher than the negative control group (P<0. 05),LDH and ALP activities in high concentration group were significantly lower than those in negative control group (P<0. 05). Sperm malformation rate and LDH, ALP ac-tivities were significantly negative correlation (r= -0. 947;-0. 845,P<0. 05). Conclusion Cola has some influ-ence on the formation of sperm abnormality.关键词
可乐/精子畸形/乳酸脱氢酶/碱性磷酸酶Key words
cola/sperm abnormality/lactate dehydrogenase/alkaline phosphatase分类
医药卫生引用本文复制引用
张岚,曹发正,刘彦麟,王齐..可乐对小鼠精子畸形及睾丸酶的影响[J].吉林医药学院学报,2015,(5):328-330,3.
