国际妇产科学杂志Issue(4)：470-472,483,4.
SUMO-1及ERα在子宫内膜癌中的表达及相关性研究
Study on Expression and Correlation of SUMO-1 and ERαin Endometrial Carcinoma
袁俐 1袁梦岚 1陈旭红 1姜忠敏 1李艳霞 1马晓芳 1刘晓智1
作者信息
- 1. 300450 天津市第五中心医院妇产科，病理科，中心实验室
- 折叠
摘要
Abstract
Objective:To detect the expression level of small ubiquitin-like modifier protein-1 (SUMO-1) and estrogen receptor alpha (ERα), and their correlation in endometrial carcinoma. Methods:50 cases of endometrial carcinoma samples and 35 cases of normal endometrial samples were collected in our hospital from 2006 January to 2013 December. The expression of SUMO-1 and ERα were detected in all tissues by immunohistochemical method, and their co-localization expression was detected by immunofluorescence method. Then the relationship between SUMO-1 and ERα, and their express level and the clinicopathological parameters were analyzed respectively. Results:The positive rates of SUMO-1 protein in endometrial carcinoma was higher than that in control group, while the expression of ERα protein was the opposite, and the difference between the two groups was statistically significant (P<0.05). The positive rate of SUMO-1 and ERαin endometrial carcinoma patients were differ in different ages, menopausal status and different histological grades (all P<0.05), but the difference was not significant in different pathology subtypes (P>0.05). The expression of SUMO-1 and ERα protein had good consistency (Kappa=0.875, Z=5.473, P=0.001). Conclusions:SUMO-1 and ERαwere co-localization in endometrial carcinoma, and may play a synergistic role in the process and development of endometrial carcinoma.关键词
癌/子宫内膜肿瘤/雌激素受体α/类泛素化修饰蛋白Key words
Carcinoma/Endometrial neoplasms/Estrogen receptor alpha/Small ubiquitin-like modifier protein引用本文复制引用
袁俐,袁梦岚,陈旭红,姜忠敏,李艳霞,马晓芳,刘晓智..SUMO-1及ERα在子宫内膜癌中的表达及相关性研究[J].国际妇产科学杂志,2015,(4):470-472,483,4.
