临床与病理杂志Issue(8)：1579-1584,6.DOI:10.3978/j.issn.2095-6959.2015.08.029
翻译后组蛋白乙酰化与骨代谢的研究进展
Progress on post-translational histone acetylation in bone metabolism
摘要
Abstract
Epigenetics is the study of mechanisms able to inlfuence gene expression in heritable manner without altering the DNA sequence. hTese mechanisms include miRNA-mediated post-transcriptional regulation, post-translational histone modiifcations and DNA methylation. Among all the histone modiifcation, histone acetylation is reserched most widely. And it has been confirmed to influence many physiological and pathological progresses. In bone metabolism, histone acetylation inlfuences osteoblastogenesis and osteoclastogenesis. hTus, it plays an important role in bone homeostasis. This review introduces the roles of histone acetylation, HDACs and HATs in bone metabolism, and we hope it will provide a new direction for the research of bone-metabolism related diseases.关键词
组蛋白乙酰化/成骨细胞/破骨细胞/组蛋白去乙酰化酶/SIRT1Key words
histone acetylation/osteoblast/osteoclast/HDACs/HATs/SIRT1引用本文复制引用
邓展涛,金洁雯(综述),徐海栋,赵建宁(审校)..翻译后组蛋白乙酰化与骨代谢的研究进展[J].临床与病理杂志,2015,(8):1579-1584,6.基金项目
江苏省省科技厅资助项目(BL2012002)；南京市科研课题(201402007)。@@@@Tis work was supported by Science and Technology Project Foundation of Jiangsu Province (BL2012002), Scientifc Research Project of Nanjing Province (201402007), P. R. China （BL2012002）
