摘要
Abstract
Objective To observe the clinical efficacy of simvastatin combined with clopidogrel on patients with unstable angina pectoris(UAP) as well as its impact on inflammatory reaction of the patients.Methods Ninety-six UAP patients were divided into Group A,Group B and Group C according to the random number table,with 32 cases in each group.All of the patients in three groups were treated with bed rest,oxygen uptake,blood vessel dilatation,vasospasm prevention,heart rate control,anticoagulation,improving myocardial oxygen consumption and other corresponding antianginal therapies.Group B was treated with 20 mg of oral simvastatin once a day.Group C was treated with 300 mg of clopidogrel for the first time,and then 75 mg of clopidogrel once a day.Group A was treated with oral simvastatin (75 mg once a day) plus clopidogrel(the administration as same as that of Group C).The treatment lasted for 8 weeks in the three groups.The clinical effects,the levels of serum C-reactive protein(CRP) before and after treatment and incidence of adverse cardiovascular events were compared among three groups.Results The total effective rates in the Group A,Group B and Group C were 90.6%,71.9%and 75.0%,respectively,Group A gained a better efficacy compared with Group B and Group C(P <0.05),but there was no significant difference in the efficacy between Group B and Group C(P >0.05).After the treatment,the serum CRP levels in the three groups were significantly lower than those before treatment,and Group A gained a lower serum CRP level after treatment compared with Group B and Group C(P <0.05),but there was no significant difference in the serum CRP level between Group B and Group C(P >0.05).The incidence of adverse cardiovascular events in Group A,Group B and Group C were 3.1%(1/32),25.0%(8/32) and 28.1%(9/32),respectively.Group A obtained a significantly lower incidence of adverse cardiovascular events compared with Group B and Group C(P <0.05),but there was no significant difference in the incidence of adverse cardiovascular events between Group B and Group C(P >0.05).Conclusion Simvastatin combined with clopidogrel has favorable clinical effects on UAP,which can decrease serum CRP level.Its mechanism might be associated with the synergistic anti-inflammatory effects of the two drugs.关键词
不稳定型心绞痛/辛伐他汀/氯吡格雷/C 反应蛋白/炎症反应Key words
Unstable angina pectoris/Simvastatin/Clopidogrel/C-reactive protein/Inflammatory reaction分类
医药卫生
