解放军医药杂志Issue(8)：9-13,5.DOI:10.3969/j.issn.2095-140X.2015.08.003
肾移植术后CYP3 A5基因多态性对他克莫司血药浓度的影响
Effect of CYP3A5 Polymorphisms on the Plasma Concentration of Tacrolimus Spansule in Patients after Renal Transplantation
摘要
Abstract
Objective To investigate the effect of Cytochrome P450(CYP)450 3A5 polymorphisms on the plas-ma concentration of Tacrolimus spansule in patients after renal transplantation. Methods A total of 63 patients with al-lograft renal transplantation during November 2012 and November 2013 were divided into experiment group (n=32) and control group (n=31) by random digits table method. The CYP3A5 genotype, Tacrolimus dose during hospital stay, plasma concentration, times of modifying dosage and the incidence rates of acute rejection ( AR) and adverse reactions in the two groups were compared. Results Compared with those in the control group, on postoperative 7th d, in the experi-ment group the ratio of finishing target concentration was significantly higher, and the ratio of patients with modifying dos-age was significantly lower (P<0. 05);the incidence rates of acute rejection (AR) and adverse reactions within postop-erative 1 month were lower, and the differences were statistically significant ( P<0. 05 ) . The AR incidence rate was higher, and the incidence rate of adverse reactions was lower within postoperative 1 month in renal transplantation patients with CYP3A5∗1/∗1&∗1/∗3 genotype than those in postoperative patients with CYP3A5∗3/∗3 genotype, and the differences were also statistically significant (P<0. 05). Conclusion Individuation of Tacrolimus dose regimen should be established based on the CYP3A5 genotype for patients after renal transplantation, which can keep stable plasma con-centrations of Tacrolimus, and reduce incidence rates of acute rejection and adverse reactions of the patients.关键词
肾移植/他克莫司/细胞色素P450酶3A5/基因多态性/血药浓度/临床方案Key words
Kidney transplantation/Tacrolimus/Cytochrome P4503A5/Genic polymorphisms/Plasma concen-tration/Clinical protocols分类
医药卫生引用本文复制引用
王曙,赖柳生,眭维国,陈洁晶,陈怀周,郭骏军,李飞,李典鹏..肾移植术后CYP3 A5基因多态性对他克莫司血药浓度的影响[J].解放军医药杂志,2015,(8):9-13,5.基金项目
广西自然科学基金(2011GXNSFB018105) （2011GXNSFB018105）
广西植物功能物质研究与利用重点实验室开放基金(FPU2011-②) （FPU2011-②）
