解放军医药杂志Issue(8)：75-78,4.DOI:10.3969/j.issn.2095-140X.2015.08.019
布拉酵母菌治疗腹泻型肠易激综合征的效果及机制分析
Effect and Mechanisms of Saccharomyces Boulardii in Diarrhea-Predominant Irritable Bowel Syndrome
摘要
Abstract
Objective To investigate the effect of Saccharomyces Boulardii on clinical symptoms improvement and inflammatory response of diarrhea-predominant irritable bowel syndrome ( IBS-D) . Methods A total of 112 patients with IBS-D admitted during January 2013 and December 2014 were randomly divided into observation group (n=56) and control group (n=56). The control group was treated with routine treatment combined with guidance for diet and lifes-tyle, while the observation group was added with Saccharomyces Boulardii on the basis of control group treatment. A course of treatment was 8 weeks. The differences of IBS-D related symptoms, and levels of serum interleukin-6 (IL-6), tumor necrosis factor-α( TNF-α) and nuclear factor-κB ( NF-κB) before and after the treatment were observed in the two groups. Results The symptoms were obviously improved in the two groups after the treatment, and the total efficiency in the observation group was significantly higher than that in control group (P<0. 01);IBS-D related symptom scores after the treatment in the two groups were significantly lower than those before the treatment ( P<0. 05 ) , and the decreased score in the observation group was more significant than that in the control group (P<0. 05). The serum IL-6, TNF-αand NF-κB levels after treatment in the observation group were significantly lower (P<0. 05);the indexes in the control group were lower than those before the treatment, but the differences were not statistically significant (P>0. 05). The differences of serum IL-6, TNF-α and NF-κB levels after the treatment in the two groups were statistically significant (P<0. 05). Conclusion Saccharomyces boulardii can adjust abnormal inflammatory reaction of IBS-D patients by in-hibiting the NF-κB activity and therefore improve the clinical symptoms.关键词
布拉酵母菌/腹泻型肠易激综合征/临床症状/炎性细胞因子/核因子-κBKey words
Saccharomyces Boulardii/Diarrhea-predominant irritable bowel syndrome/Clinical symptoms/In-flammatory cytokines/Nuclear factor-κB分类
医药卫生引用本文复制引用
李超,崔立红,贺星,王晓辉,闫志辉,弓三东..布拉酵母菌治疗腹泻型肠易激综合征的效果及机制分析[J].解放军医药杂志,2015,(8):75-78,4.基金项目
吴阶平医学基金会临床科研专项基金(320.6750.13175) （320.6750.13175）
