郑州大学学报（医学版）Issue(5)：606-610,5.DOI:10.13705/j.issn.1671-6825.2015.05.004
类风湿关节炎患者外周血 Th17细胞及 Treg 细胞数量的 meta分析
Quantity of Th17 and Treg cells in the peripheral blood from patients with rheumatoid arthritis:a meta analysis
摘要
Abstract
Aim:To study the changes of Th17 and Treg cells in peripheral blood from patients with rheumatoid arthritis (RA), and to clarify the relationship between the changes of quantity of the two cells and the incidence of RA.Methods:The quality evaluation of the quality assessment tool for Scale Newcastle-Ottawa (NOS) was used to evaluate the methodological qual-ity of the study.The heterogeneity of the selected articles was tested, and the results of heterogeneity test were selected to choose the fixed effect model or random effect model.The funnel plot test was used to examine the publication bias.Results:A total of 22 studies were included in the analysis of 1 287 subjects.SMD of Th17 and Treg cells in RA patient and normal people were 1.04(0.76,1.33), -0.43(-0.72,-0.15).The number of Th17 cells in peripheral blood of patients with RA was increased, while the number of Treg cells decreased.Conclusion:The increased number of Th17 cells and the decreased number of Treg cells in peripheral blood may correlate with the occurrence of RA .关键词
类风湿关节炎/Th17/Treg/meta分析Key words
rheumatoid arthritis/Th17/Treg/meta analysis分类
医药卫生引用本文复制引用
刘运夏,朱彦锋,刘杨,曲绍娟,李云..类风湿关节炎患者外周血 Th17细胞及 Treg 细胞数量的 meta分析[J].郑州大学学报（医学版）,2015,(5):606-610,5.基金项目
国家自然科学基金项目81372983 （）
