郑州大学学报（医学版）Issue(5)：611-613,3.DOI:10.13705/j.issn.1671-6825.2015.050.05
臭氧急性暴露对豚鼠肺组织中 NO 水平的影响
Effect of acute ozone exposure on the level of NO in guinea pigs ′lung tissue
摘要
Abstract
Aim:To study the effect of acute ozone exposure on the level of nitric oxide ( NO) in the lung tissue of guinea pigs .Methods:Twenty adult guinea pigs were randomly allocated into control group and ozone exposure group ,each group of10 guinea pigs, half male and half female.The ozone exposure group was exposed to volume fraction of 0.000 1%ozone for 3 hours.The NO kit and NO synthase(NOS) kit were used to measure the content of NO and NOS activity in lung tissue of guinea pigs′respectively.Results:Compared with control group , the level of NO in the lung tissue of ozone expo-sure group was significantly increased (t=3.487,P=0.003), while the level of NOS activity kept steady (Z=0.522,P=0.602).Conclusion:1 ppm ozone exposure to guinea pigs can increase the level of NO in the lung tissue , which may not be mediated by NOS .关键词
臭氧/急性暴露/豚鼠/一氧化氮/一氧化氮合酶Key words
ozone/acute exposure/guinea pig/nitric oxide/nitric oxide synthase分类
医药卫生引用本文复制引用
段丽菊,隋美丽,赵凝秋,李思晨,王如群,胡婕,陈彬翰..臭氧急性暴露对豚鼠肺组织中 NO 水平的影响[J].郑州大学学报（医学版）,2015,(5):611-613,3.基金项目
国家自然科学基金青年科学基金项目81302402；河南省教育厅科学技术研究重点项目12 B330004 （）
