中国当代医药Issue(22)：4-6,11,4.
花青素对动脉粥样硬化模型小鼠抗氧化和血脂代谢的影响
Effect of cyanidine on antioxidant and lipids metabolism in arteriosclero-sis mode mice
摘要
Abstract
Objective To explore the effect of cyanidine on antioxidant capacity and lipids metabolism in arterioscle-rosis mode mice. Methods After ApoE-/-mice were given high fat diet for 8 weeks,they were intragastric administrated different dose of cyanidine (low,media and high:50,100 and 200 mg/kg respectively) for continuous 8 weeks.Serum and livers of the mice were acquired and various index of antioxidant and levels of lipids were tested. Results At media and high dose,the improved activation of SOD in serum and the decreased levels of MDA in serum and livers had signifi-cant difference compared with control group(P<0.05).The activation of SOD in livers had significant difference(P<0.05). Various index of lipids such as TC,TG and LDL-C decreased with the increase of dose.TG in media and high dose had significant difference,while TC and LDL-C in high dose had significant difference compared with control group (P<0.05). Conclusion Cyanidine has the functions of antioxidant and decreasing lipids in high fat diet-inducedarterioscle-rosis mice.关键词
花青素/ApoE-/-小鼠/氧化/血脂/动脉粥样硬化Key words
Cyanidine/ApoE-/-mice/Oxidant/Lipid/Arteriosclerosis分类
医药卫生引用本文复制引用
欧海龙,张庆海..花青素对动脉粥样硬化模型小鼠抗氧化和血脂代谢的影响[J].中国当代医药,2015,(22):4-6,11,4.基金项目
贵州省教育厅项目 （）
