解放军医学院学报Issue(8)：769-772,844,5.DOI:10.3969/j.issn.2095-5227.2015.08.002
乳腺癌复发转移前后激素受体、HER-2表达的改变及其临床意义
Discordance in receptor status between primary and recurrent breast cancer and its clinical significance
王英哲 1司文 1杨俊兰2
作者信息
- 1. 解放军总医院 肿瘤内科，北京 100853
- 2. 南开大学医学院，天津 300071
- 折叠
摘要
Abstract
Objective To investigate the discordance expression of estrogen receptor (ER), progesterone receptor (PR), and Her-2 between primary and recurrent tumors in patients with recurrent breast cancer and its effect on disease-free survival (DFS).Methods One hundred and seventy-five women with recurrent breast cancer who underwent biopsyin Chinese PLA General Hospital from April 1, 1999 to August 31, 2013 were enrolled in this study, the expression of ER and PR were tested in 175 patients while the Her-2 status was ascertained in 128 patients.Results Discordance in ER, PR, and Her-2 between the primary and the recurrent was 35.4% (McNemar's testP=0.003), 39.4% (P=0.030), and 14.8% (P=0.001), respectively. The positive conversion rate of ER and PR were 10.9% and 14.3%, and the negative conversion rate were 24.6% and 25.1% which were higher than the positive conversion rate (PER=0.003,PPR=0.030). The positive and negative conversion rate of Her-2 were 13.3% and 1.6%, the former was higher than the later (P=0.001). The discordance in ER and Her-2 between the primary and the recurrent was relevant to tumor size (PER=0.010, PHer-2=0.042). A statistically tendency in DFS to intra individual HR status and Her-2 status in primary tumor and relapse was noted. Conclusion Breast cancer is a highly heterogeneous disease. Some patients with breast cancer experience altered HR and Her-2 status throughout tumor progression. The molecular classification of breast cancer is associated with DFS possibly. The discordance in HR and Her-2 between the primary and the recurrent is relevant to tumor size. Once breast cancer relapses, it may show higher degree of malignant.关键词
晚期乳腺癌/雌激素受体/孕激素受体/Her-2/无病生存期Key words
advanced breast cancer/estrogen receptor/progesterone receptor/Her-2/disease-free survival分类
医药卫生引用本文复制引用
王英哲,司文,杨俊兰..乳腺癌复发转移前后激素受体、HER-2表达的改变及其临床意义[J].解放军医学院学报,2015,(8):769-772,844,5.
