解放军医学院学报Issue(8)：786-788,793,4.DOI:10.3969/j.issn.2095-5227.2015.08.006
人类免疫缺陷病毒阳性患者经高效抗逆转录病毒治疗血液学指标变化
Hematological parameters changes in HIV positive patients taking active antiretroviral treatment
王晗 1朱剑功 1赵丽丽 1耿伟 1谢娜 2李妍 1杨宁 1李沛然 1何叶莉 1郭桐生1
作者信息
- 1. 解放军302医院临床检验医学中心 全军感染病临床实验诊断中心，北京 100039
- 2. 解放军302医院感染门诊，北京 100039
- 折叠
摘要
Abstract
Objective To investigate hematological parameters changes in human immunodeficiency virus (HIV) positive patients taking active antiretroviral treatment and explore its clinical significance.Methods One hundred HIV positive patients admitted to our hospital from November 2013 to December 2014 were enrolled in this study, and they were divided into two groups: highly active antiretroviral therapy (HAART) group (n=55) and HARRT naïve group (n=45). The levels of peripheral blood CD3+, CD3+ CD4+ and CD3+CD8+ T-lymphocytes were detected by flow cytometry. WBC, RBC, Hgb, HCT, MCV, MCH, MCHC, RDW, PLT, and MPV were determinedby nucleic acid fluorescent dye method and flow cytometry. PT and PTA levels were detected by immunoturbidimetry. HIVRNA were determined by fluorescent quantitation PCR methods, and the characteristics of hematological parameters in HIV positive patients taking active antiretroviral treatment were observed.Results There was no statistically significant difference between observation group and control group in hematology indexes (P>0.05). Prevalence of anemia, leucopenia, thrombocytopenia, neutropenia and lymphopenia were 12.0%, 36.0%, 4.0%, 28.0% and 5.3% in patients taking HAART and 30.7%, 16.9%, 9.2%, 13.8% and 4.6% in HAART naïve patients respectively. There were significant differences in total WBC, RBC, Hgb, MCV, MCH, MCHC, MPV and CD4 counts between patients taking HAART and HAART naïve patients (P<0.05).ConclusionHAART can reduce the incidence of anemia and thrombocytopenia in patients with HIV, but it is prone to have leucopenia, neutropenia and lymphopenia. Clinicians need to take consideration about drug combination, course of treatment and treatment taboo in HIV positive patients according to changes of hematological indexes.关键词
艾滋病毒/高效抗逆转录病毒治疗/贫血/白细胞减少症Key words
human immunodeficiency virus/highly active antiretroviral therapy/anemia/leucopenia分类
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王晗,朱剑功,赵丽丽,耿伟,谢娜,李妍,杨宁,李沛然,何叶莉,郭桐生..人类免疫缺陷病毒阳性患者经高效抗逆转录病毒治疗血液学指标变化[J].解放军医学院学报,2015,(8):786-788,793,4.
