解放军医学院学报Issue(8)：829-831,835,4.DOI:10.3969/j.issn.2095-5227.2015.08.018
TLR-2和TLR-4受体单核苷酸多态性与鲍曼不动杆菌感染的相关性
Correlation of single nucleotide polymorphisms in TLR2 and TLR4 receptors with Acinetobacter baumanii infection
摘要
Abstract
Objective To determine the correlation of SNP polymorphisms of TLR2 and TLR4 gene with Acinetobacter baumanii infection and provide basis for early prevention of Acinetobacter baumanii infection.Methods Four hundred and twenty- three Acinetobacter baumanii infected patients and 385 patients collected from the same ward were selected as expertimental group and control group, respectively. The candidate SNPs at TLR-2 (rs3804099, rs7656411 and rs76112010) and TLR-4 (rs1927914, rs10759932 and rs11536889) were selected according to their frequency (>5%), position, and their associations with infectious diseases reported previously. SNP genotyping was performed using an improved multiplex ligation detection reaction (iMLDR) technique. The relationship between Acinetobacter baumanii infection and SNPs polymorphisms of TLR2 and TLR4 was analyzed by multiple logistic regression model.Results All SNPs were in Hardy-Weinberg equilibrium (HWE). The hyplotype distribution of TLR2 and TLR4 candidate alleles showed no significant difference between infected patients and controls, while the haplotype GCG of TLR-4 was significantly associated with Ab infection (P=0.027). Conclusion Our studies suggest that the two SNPs (rs1927914 and rs10759932) of TLR-4 may be related to the susceptibility to Ab infection.关键词
鲍曼不动杆菌/基因多态性/Toll样受体Key words
Acinetobacter baumanii/gene polymorphism/toll-like receptors分类
医药卫生引用本文复制引用
林茂虎,朱晓应,苗芮,何蕾,贾宁..TLR-2和TLR-4受体单核苷酸多态性与鲍曼不动杆菌感染的相关性[J].解放军医学院学报,2015,(8):829-831,835,4.基金项目
国家自然科学基金项目(30972523；31140046)Supported by the National Natural Science Foundation of China(30972523 （30972523；31140046）
31140046) （）
