检验医学与临床Issue(16)：2333-2335,3.DOI:10.3969/j.issn.1672-9455.2015.16.014
尿液对羟基苯丙氨酸检测在恶性肿瘤早期预测中的应用价值
Application value of urine hydroxyl phenylalanine in early predicting malignant tumor
摘要
Abstract
Objective To discuss the clinical application value of urine hydroxyl phenylalanine in predicting malignant tumor .Methods Hydroxyl phenylalanine in 395 urine samples (90 healthy subjects ,92 patients with be‐nign tumor ,213 patients with malignant tumor) was detected by the hydroxy phenylalanine kits .Results The posi‐tive detection rate was 8 .89% in the normal group ,14 .13% in the benign tumor group and 68 .54% in the malignant tumor group .Compared with the normal group ,the positive detection rate in the benign tumor group had no obviously difference (P>0 .05);Compared with the benign tumor group ,the positive detection rate in the malignant tumor group was obviously increased with statistical difference(P<0 .05);the positive detection rate was 78 .82% in diges‐tive tract malignant tumor ,72 .22% in nasopharyngeal carcinoma ,71 .42% in lymphoma ,65 .38% in breast cancer , 62 .50% in gynecologic malignant tumors ,60 .00% in lung cancer and 72 .22% in other malignant tumors .The posi‐tive detection rates had no statistical differences among different types of tumor (P>0 .05) .The sensitivity ,specifici‐ty ,accuracy ,positive predictive value and negative predictive value of urine hydroxyl phenylalanine for predicting ma‐lignant tumor were 68 .54% ,88 .46% ,77 .72% ,87 .00% and 71 .00% ,respectively .Conclusion Urine hydroxy phen‐ylalanine as a new tumor marker is suitable for the broad spectrum screening of malignant tumor ,which has an im‐portant significance for the differentiation diagnosis of benign and malignant tumors .关键词
尿液对羟基苯丙氨酸/恶性肿瘤/筛查Key words
urine hydroxy phenylalanine/malignant tumor/screening引用本文复制引用
黄学梅,吴立翔,吕自兰,李影,郭变琴..尿液对羟基苯丙氨酸检测在恶性肿瘤早期预测中的应用价值[J].检验医学与临床,2015,(16):2333-2335,3.基金项目
重庆市自然科学基金项目（cstc2014jcyjA1633）。 （）
