检验医学与临床Issue(16)：2371-2374,4.DOI:10.3969/j.issn.1672-9455.2015.16.029
抑郁症复发患者甲状腺功能减退与认知功能障碍的相关性
Correlation between hypothyroidism and cognitive dysfunction in patients with recurrence of depression
陈英 1朱建宏 2余彦君1
作者信息
- 1. 陕西省西安市精神卫生中心检验科 710061
- 2. 西安交通大学第二附属医院检验科，西安 710061
- 折叠
摘要
Abstract
Objective To analyze the correlation between hypothyroidism and cognitive dysfunction in the pa‐tients with recurrence of depression .Methods 240 patients with depression in the Xi′an Mental Health Center were chosen and divided into the first onset group and relapse group according to the depression onset situation .The differ‐ences in the cognitive function score ,thyroid hormone level ,serum folic acid(FA) and homocysteine(HCY) levels were analyzed ,and the correlation between each factor with the cognitive function impairment were analyzed .Results The various scores of the relapse group were obviously lower than those in the first onset group and the control , the differences were statistically significant (P<0 .05) .The further research found that the serum levels of T4 and FT4 in the relapse group were lower than those in the control group and the first onset group ,while the TSH level was higher ,the differences were statistically significant (P<0 .05) .Moreover ,the serum HCY level was increased and the FA level was decreased in the relapse group compared with the control and the first onset group ,the differ‐ences were statistically significant (P<0 .05) .The correlation analysis indicated that serum levels of TSH and HCY were negatively correlated with MMSE ,while the T4 ,FT4 and FA levels were positively correlated with MMSE . Conclusion This research confirms that hypothyroidism is correlated with the cognitive impairment in the patients with recurrence of depression ,which might be led by rising of HCY level and decreasing of FA level ,thus lays a foun‐dation for the related study of correlation between recurrence of depression with the cognitive function impairment and provides a molecular target for clinical treatment .关键词
抑郁症复发/甲状腺功能/同型半胱氨酸/叶酸/认知功能Key words
recurrence of depression/thyroid axis function/HCY/FA/cognitive function引用本文复制引用
陈英,朱建宏,余彦君..抑郁症复发患者甲状腺功能减退与认知功能障碍的相关性[J].检验医学与临床,2015,(16):2371-2374,4.
