四川精神卫生Issue(4)：310-313,4.DOI:10.11886/j.issn.1007-3256.2015.04.007
精神分裂症患者血脂水平对奥氮平血浆药物浓度的影响
Influence of blood lipid levels on olanzapine plasma concentrations in schizophrenic patients
摘要
Abstract
Objective To investigate the relationship between blood lipid levels and plasm concentrations of olanzapine in schiz-ophrenic patients. Methods A total of 104 schizophrenic patients treated with olanzapine were divided into hyperlipidemic group(n= 29)and normolipidemic group(n = 75),according to the diagnosetic criterion of the Prevention and Therapy Guidlines about Chi-nese Adults Dyslipdidemia published in 2007. Triglyceride(TG),total cholesterol(TC),high - density lipoprotein cholesterol(HDL- C),low - density lipoprotein cholesterol(LDL - C),renal function(creatinine,urea),hepatic function(albumin,alanine trans-aminase(ALT),aspartate transaminase(AST)and olanzapine plasma concentrations were messured. Results There was no signifi-cant difference in gender,age,urea,renal function(creatinine,albumin),hepatic function(ALT,AST)between two groups(P >0. 05). There was no significant difference in olanzapine doses between two groups(P >0. 05),but the olanzapine plasma concentrations of hyperlipidemic group was significant lower than that of normolipidemic group(P <0. 05). Multiple linear regression analysis showed that triglyceride(TG)was a independent factor influencing the olanzapine plasma concentrations,regression coefficient was negative(P <0. 05). Conclusion Hypertriglyceride probably decreased olanzapine plasma concentrations in schizophrenic patients.关键词
血脂水平/奥氮平/血浆浓度Key words
Blood lipid levels/Olanzapine/Plasma concentrations分类
医药卫生引用本文复制引用
袁道瑞,张向荣,陆蓉,李海林..精神分裂症患者血脂水平对奥氮平血浆药物浓度的影响[J].四川精神卫生,2015,(4):310-313,4.基金项目
南京医科大学科技发展基金（2012NJMU117）；国家临床重点专科建设项目（精神科，卫生部医政司2011-873）；江苏省医学重点学科 （）
