摘要
Abstract
Objective To investigate the clinical efficacy and safety of Ziprasidone injection on the therapy of acute agitation symptom of childhood schizophrenia. Methods 70 subjects with acute agitation symptoms conform to ICD - 10 for schizophrenia were randomly assigned into two groups,the research group(n = 35)were given ziprasidone injection,and the control group(n = 35)were given haloperidol injection for 3 days. Before and after treatment 2,12,24,48,72h of the respectively Positive and Negative Syn-drome Scale(PANSS)reduction rate,the end of the Clinical Global Impression Scale(CGI)were assessed. At the end of the treat-ment,the Treatment Emergent Symptom Scale(TESS)was assessed. Results At the end of the treatment,PANSS reduction rate was 46. 92% in the research group and the control group was 49. 46% ,the clinical improvement rate was 77. 14% in the research group and the control group was 80. 00% . No statistically significant differences between the two groups were found on efficacy(P > 0. 05). Adverse effects rate in the research group was 20. 00% ,the control group was 37. 14% ,there was significant difference between the two groups(P < 0. 05). Conclusion Ziprasidone injection is effective and haloperidol rather in treating the acute agitation symptoms of childhood schizophrenia,the rate of extrapyramidal adverse reaction was low.关键词
齐拉西酮注射液/氟哌啶醇注射液/儿童精神分裂症/急性激越症状Key words
Ziprasidone injection/Haloperidol injection/Childhood schizophrenia/Acute agitation symptoms分类
医药卫生
