四川精神卫生Issue(4)：321-323,3.DOI:10.11886/j.issn.1007-3256.2015.04.010
脑电生物反馈联合米氮平治疗焦虑障碍的临床对照研究
Comparative study on EEG - biofeedback therapy combined with mirtazapine in treatment of anxiety disorder
摘要
Abstract
Objective To explore the efficacy and adverse effect of EEG - biofeedback therapy with mirtazapine in the treatment of anxiety disorder. Methods 97 cases anxiety disorder patients according to the Diagnostic and Statistical Manual of Mental Disorders Fourth edition(DSM - IV)were randomly divided into study group(n = 48)and control group(n = 49). Each group was given mir-tazapine for 6 weeks,meanwhile the study group accepted 16 times EEG - biofeedback therapy. The efficacy was assessed using the Hamilton Anxiety Scale(HAMA)and Self - rating Anxiety Scale(SAS). Treatment Emergent Symptom Scale(TESS)was used to e-valuate the adverse effect. Results The scores of HAMA and SAS after treatment were significantly decreased than before treatment(P< 0. 05)in two groups. Comparing with the control group,the scores of HAMA and SAS in study group were higher in the end of 2nd , 4th and 6th week of the treatment(P < 0. 05). 6 weeks after treatment,the effective rate in study group was 77. 1% and control group was 51. 0% ,the difference was statistically significant between two groups(P < 0. 05). Conclusion Mirtazapine combined with EEG- biofeedback therapy may be more effective than mirtazapine monotherapy for anxiety disorder,but no increase in the adverse effect.关键词
焦虑障碍/脑电生物反馈/米氮平Key words
Anxiety disorder/EEG - biofeedback therapy/Mirtazapine分类
医药卫生引用本文复制引用
高月霞,石晓华,黄敬,李红光,刘华丽,刘德芳,余红,封亚,朱先红,杨杰..脑电生物反馈联合米氮平治疗焦虑障碍的临床对照研究[J].四川精神卫生,2015,(4):321-323,3.基金项目
华北油田矿区医疗卫生临床医学相关研究 （）
