中国组织工程研究2015，Vol.19Issue(30)：4837-4841,5.DOI:10.3969/j.issn.2095-4344.2015.30.016
聚四氟乙烯联合Ⅰ型胶原作为隆鼻高分子材料的生物相容性
Biocompatibility of polytetrafluoroethylene combined with type I collagen as a nose filler material
尹中普 1孙晓2
作者信息
- 1. 南阳市中心医院,耳鼻喉头颈外科,河南省南阳市 473003
- 2. 南阳市中心医院,消化内科,河南省南阳市 473003
- 折叠
摘要
Abstract
BACKGROUND:Polytetrafluoroethylene (PTEE) as a nose filer material has advantages on the resistant to corrosion, chemical stability and so on. However, its linear expansion coefficient is large easily leading to infection and rejection, and its application has some limitations. OBJECTIVE:To compare the cel toxicity, inflammatory infiltrates and biocompatibility indexesin vivo between PTEE and PTEE combined with type Ⅰ colagen. METHODS: MTT method was used to detect the relative proliferation rate of L929 cels cultured with PTEE extract or PTEE combined with type Ⅰ colagen extract; an electron microscope was used to observe the cel growth. PTEE or PTEE combined with type Ⅰ colagen was embedded under the nasal dorsal fascia of New Zealand white rabbits for 7 days, and hematoxylin-eosin staining was used to detect whether nasal mucosa epithelial tissue had inflammatory infiltration. Systemic toxicity, alergies, pyrogen reaction and deaths of rabbits were observed after injection of two kinds of material extracts by ear vein. RESULTS AND CONCLUSION: The cytotoxicity and inflammatory infiltration were milder in PTEE combined with type Ⅰ colagen group than PTEE group (P < 0.05). The alergic reactions and pyrogen reactions were fewer in PTEE combined with type Ⅰ colagen group than PTEE group (P < 0.05). These findings indicate that PTEE combined with type Ⅰ colagen as the nose filer material has better biocompatibility.关键词
生物材料/材料相容性/聚四氟乙烯/聚四氟乙烯联合Ⅰ型胶原/鼻填充材料/生物相容性分类
医药卫生引用本文复制引用
尹中普,孙晓..聚四氟乙烯联合Ⅰ型胶原作为隆鼻高分子材料的生物相容性[J].中国组织工程研究,2015,19(30):4837-4841,5.
