现代医药卫生Issue(16)：2426-2428,3.DOI:10.3969/j.issn.1009-5519.2015.16.007
响应面法优化葛根素提取工艺的研究
Study on response surface method for optimizing puerarin extraction process
王婴 1伍艳芬1
作者信息
- 1. 广东药学院医药化工学院，广东中山528458
- 折叠
摘要
Abstract
Objective To optimize the extraction technological parameters of Radix Puerariae in order to improve the ex-traction ratio of puerarin. Methods Based on the single factor preliminary screening ,with the puerarin content detected by HPLC as the response value,the three-factor and three-level Box-Behnken test design was carried on. The experimental data were ana-lyzed by using the Design-Expert software. Results The interaction action existed between the ethanol concentration and extrac-tion time,between the extraction time and solid-liquid ratio and between the ethanol concentration and solid-liquid ratio. The opti-mal extraction conditions of puerarin were the ethanol concentration of 78%,the extraction time of 143 min and the solid to liquid ratio of 1∶10. Conclusion The optimized technological extraction conditions are simple with good reproducibility and suitable for the extraction of puerarin.关键词
葛根素/中药制药工艺/工艺学/多元分析/乙醇Key words
Puerarin/Pharmaceutical technology/Technology/Multivariate analysis/Ethanol引用本文复制引用
王婴,伍艳芬..响应面法优化葛根素提取工艺的研究[J].现代医药卫生,2015,(16):2426-2428,3.
