中国老年保健医学Issue(4)：14-16,17,4.DOI:10.3969/j.issn.1672-4860.2015.04.003
DNA甲基化与健康长寿的研究进展
Advance in relationship between DNA methylation and healthy ageing and longevity
摘要
Abstract
Epigenetic modifications play an important role in the process of gene regulation.And inhibition of disease genes in longevity and health of individuals may have also been associated with epigenetic modifications, contributing to the phenotype of lon-gevity and healthy.Age-related DNA methylation is involved in metabolic disease, cardiovascular disease, and cancer in elderly.The evidence is limited about genetic variations in longevity and anti-aging effect, but in recent years, the role of DNA methylation chan-ges in human has been reported extensively throughout the entire life, which is affected by gender and age, this will be helpful to un-derstand the nature of life.Although the reason for cause of DNA methylation and the exact mechanism still needs further research, it is still promisingto understand aging, anti-aging, and individualized “accurate” monitoring of effect of intervention.关键词
健康长寿/衰老/DNA甲基化/表观遗传/个体化Key words
healthy longevity/ageing/DNA methylation/epigenetics/individualized引用本文复制引用
孙亮,杨泽..DNA甲基化与健康长寿的研究进展[J].中国老年保健医学,2015,(4):14-16,17,4.基金项目
北京市科技新星计划（Z121107002512058）；国家自然科学基金（30972709，81061120527，81241082，81370445）；卫生部公益性研究基金（201302008）；国家科技部十二五支撑计划项目 （）
