中国全科医学Issue(20)：2471-2474,4.DOI:10.3969/j.issn.1007-9572.2015.20.027
埃索美拉唑联合早期肠内生态免疫营养对重症急性胰腺炎患者肠黏膜屏障功能的影响
Effects of Esomeprazole Combined With Early Enteral Ecoimmunonutrition on Intestinal Mucosal Barrier Function in Patients With Severe Acute Pancreatitis
田笑笑 1杜浩 1白艳丽 1朱晶晶 1张瑜 1张亚历2
作者信息
- 1. 471003 河南省洛阳市，河南科技大学第一附属医院消化内科，骨外科
- 2. 南方医科大学南方医院消化内科
- 折叠
摘要
Abstract
Objective To analyze the effects of esomeprazole combined with early enteral ecoimmunonutrition on intestinal mucosal barrier function in patients with severe acute pancreatitis( SAP). Methods We enrolled 68 SAP patients who were admitted into the Department of Gastroenterology and the ICU of the First Affiliated Hospital of Henan University of Science and Technology from January 2012 to June 2014. According to different nutrition methods,the subjects were divided into three groups:TPN group(n=21),EIN group(n=24)and E+EIN group(n=23). The indicators of intestinal mucosal barrier function after intervention were examined and analysed,including the levels of plasma endotoxin,D-lactate,diamine oxidase (DAO)and lactulose/mannitol(L/M)in urine. Results On Day 7 and 14,the three groups were higher(P<0. 05)in the indicators than before intervention. The EIN group and E + EIN group were lower than TPN group in the levels of plasma endotoxin,D-lactate,DAO and L/M in urine(P<0. 05),and the E+EIN group was lower(P<0. 05)than the EIN group in the indicators. Conclusion Esomeprazole combined with early enteral ecoimmunonutrition could effectively protect intestinal mucosal barrier and maintain its integrity. The effect is better than simply using EIN or TPN.关键词
胰腺炎/肠道营养/埃索美拉唑/肠黏膜Key words
Pancreatitis/Enteral nutrition/Esomeprazole/Intestinal mucosa分类
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田笑笑,杜浩,白艳丽,朱晶晶,张瑜,张亚历..埃索美拉唑联合早期肠内生态免疫营养对重症急性胰腺炎患者肠黏膜屏障功能的影响[J].中国全科医学,2015,(20):2471-2474,4.
