中国实验动物学报Issue(4)：401-405,5.DOI:10.3969/j.issn.1005-4847.2015.04.013
甘草酸脂质体的制备及小鼠体内肝靶向效率的评价
Preparation of glycyrrhizic acid liposomes and evaluation its liver targeting property in mice
摘要
Abstract
Objective To prepare liposomes of glycyrrhizic acid, and evaluate its liver targeting property in mice. Methods The liposomes were prepared with conventional rotary-evaporated film-ultrasonication method.The liposomes were injected into the mouse tail vein, and the concentration of glycyrrhizic acid was detected by RP-HPLC.The glycyrrhiz-ic acid injection was taken as control.The targeted indicators, including the relative tissue exposure ( re ) , targeting effi-ciency (te), and index of peak concentration ratio (Ce), were used to evaluate the liver targeting property.Results The re was 1.4, Te of the liposomes was 0.092, and te of the injection was 0.059.The Ce of the liver was 1.59, and the Ce of the blood was 0.99.Conclusion Compared with glycyrrhizic acid injection, the glycyrrhizic acid liposomes show good liv-er-targeting property.关键词
甘草酸/脂质体/肝靶向Key words
Glycyrrhizic acid/Liposome/Liver targeting property/Mice分类
生物科学引用本文复制引用
扈本荃,廉江平,徐玥,王燕,张韫,张博..甘草酸脂质体的制备及小鼠体内肝靶向效率的评价[J].中国实验动物学报,2015,(4):401-405,5.基金项目
陕西省教育厅科学研究计划项目（编号2013JK0775）。 （）
