中国比较医学杂志Issue(8)：27-30,43,5.DOI:10.3969/j.issn.1671.7856.2015.008.006
高糖高脂饮食诱导大鼠代谢综合征模型并发阿尔茨海默样变
Alzheimer’ s disease-like lesions may occur in and accompany the high-sugar high-fat diet-induced rat models of metabolic syndrome
摘要
Abstract
Objectives To explore the relativity between Alzheimer ’ s disease ( AD)-like lesions and metabolic syndrome models induced by high-sugar high-fat diet in rats.Methods Forty-eight Sprague Dawley rats were randomly divided into 2 groups.The control group (fed with normal diet, 12 rats) and high sugar and high fat group (fed with high-sucrose and high-fat diet, 12 rats) continuously for 12 months.At the end of 6, 9 and 12 months of the experiment , we observed the animal body weight and visceral fat weight .The blood lipid levels , blood glucose and MS-related biochemical parameters were determined . The brain tissues were examined by histopathology . The characteristic AD molecules hippocampus Aβand Tau were detected using ELISA and Western blotting to confirm the presence of AD lesions in the brain.Results Compared with the normal control group , the body weight and visceral fat weight of the rats in the high-sugar high-fat groups were significantly increased; the levels of TG , FPG, LDL, HOMA-IR and hippocampus Aβ,phosphorylated Tau (p-Tau) were higher, but the level of HDL was decreased (P<0.05 for all).The histopathological examination revealed inflammatory cell infiltration in the brain tissues .Conclusions Characteristic AD-like lesions may occur and accompany the rat models of metabolic syndrome , induced by high-sugar high-fat diet, and provide a new idea for the construction of Alzheimer ’ s disease animal models .关键词
阿尔茨海默病/代谢综合征/炎症/胰岛素抵抗/高糖高脂Key words
Metabolic syndrome/Alzheimer’ s disease, sporadic/Inflammation/Insulin resistance/High-sugar high-fat diet/Rats分类
医药卫生引用本文复制引用
牛利,韩德五,许瑞龄,周鑫,屈重霄..高糖高脂饮食诱导大鼠代谢综合征模型并发阿尔茨海默样变[J].中国比较医学杂志,2015,(8):27-30,43,5.基金项目
国家自然科学青年基金（No．81302220）；山西省自然科学青年基金（编号2014021040－3）。 （）
