中国医学创新Issue(23)：39-42,4.DOI:10.3969/j.issn.1674-4985.2015.23.014
可溶性纤溶酶原激活物受体在社区获得性肺炎中的表达及临床意义
Expression and Clinical Significance of suPAR in Patients with Community-Acquired Pneumonia
摘要
Abstract
Objective:To investigate the expression and clinical significance of soluble urokinase-type plasminogen activator receptor (suPAR) in patients with CAP.Method:The plasma suPAR levels of 61 adult patients with CAP and 60 healthy patients were measured by the method of enzyme-linked immunosorbent assay(ELISA).The levels of CRP、WBC and PCT of all research objects were measured.The APACHE Ⅱ and CURB-65 scores were evaluated when the patients were hospitalized. The relationship between plasma suPAR and PCT,CRP,CURB-65 score,APACHEⅡ score,length of stay were analyzed. Result:Before treatment,the suPAR,CRP、WBC and PCT levels in patients with CAP were significantly higher than those in the control group,after treatment,the suPAR,CRP、WBC and PCT levels of CAP patients were lower than before treatment, the differences above were all statistically significant(P<0.01).The hospital stays,CURB-65 score,APACHEⅡ score and the suPAR,CRP,WBC,PCT levels in the SCAP patients were much higher than those in the NSCAP patients,the differences were all statistically significant(P<0.01).The plasma levels of suPAR was correlated with the CURB-65 score,APACHEⅡ score,length of hospital stay and levels of CRP,PCT.Conclusion:suPAR may play a role in the diagnosis and clinical assessment of the severity of CAP,it has a certain value in guiding therapeutic.关键词
可溶性纤溶酶原激活物受体/社区获得性肺炎/CURB-65评分/APACHEⅡ评分Key words
Soluble urokinase-type plasminogen activator receptor/Community-acquired pneumonia/CURB-65 score/APACHE Ⅱ score引用本文复制引用
孙逊,朱学创,郝玉贵,尹超,马彬,刘思管,程文伟..可溶性纤溶酶原激活物受体在社区获得性肺炎中的表达及临床意义[J].中国医学创新,2015,(23):39-42,4.基金项目
枣庄科技计划项目资助课题 （）
